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BCL-2 Blocks Perforin-induced Nuclear Translocation of Granzymes Concomitant with Protection against the Nuclear Events of Apoptosis

Jans, David A; Suvorova, A A; Jans, Patricia; Froelich, Christopher; Trapani, Joseph A


Cytolytic granule-mediated target cell killing is effected in part through the synergistic action of the membrane-acting protein perforin and serine proteases such as granzymes (Gr) A and B. In this study, we examine the subcellular distribution of granzymes in the presence of perforin and the induction of apoptosis in mouse FDC-P1 myeloid and YAC-1 lymphoma cells that express the proto-oncogene bcl2. Using confocal laser scanning microscopy to visualize and quantitate subcellular transport of...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.274.7.3953


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