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Hepatic Artery Flow and Propranolol Metabolism in Perfused Cirrhotic Rat Liver

Le Couteur, D; Hickey, Haruyo; Harvey, Peta; Gready, Jill; McLean, Allan J


The oxygen limitation theory states that capillarization of the sinusoidal endothelium in cirrhosis impairs hepatocellular oxygen uptake manifesting as a reduction in oxygen-dependent enzyme activity including phase I drug metabolism. The hepatic artery supplies highly oxygenated blood to the liver. Therefore, we tested whether augmentation of hepatic arterial blood flow could improve hepatic oxygenation and function in cirrhosis. Rats were treated with carbon tetrachloride and phenobarbitone...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Pharmacology and Experimental Therapeutics


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