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Cardiac Ryanodine Receptor Activity is Altered by Oxidising Reagents in Either the Luminal or Cytoplasmic Solutions

Eager, K; Dulhunty, Angela


The location of reactive cysteine residues on the ryanodine receptor (RyR) calcium release channel was assessed from the changes in channel activity when oxidizing or reducing reagents were added to the luminal or cytoplasmic solution. Single sheep cardiac RyRs were incorporated into lipid bilayers with 10-7 M cytoplasmic Ca2+. The thiol specific-lipophilic- 4,4'-dithiodipyridine (4,4'-DTDP, 1 mM), as well as the hydrophilic thimerosal (1 mM), activated and then inhibited RyRs from either the...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Membrane Biology
DOI: 10.1007/s002329900484


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