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Enhancement of Polylysine-Mediated Transferrinfection by Nuclear Localization Sequences: Polylysine Does Not Function as a Nuclear Localization Sequence

Chan, Chee Kai; Jans, David A


Polylysine (pLy) has been used successfully as a DNA carrier in receptor-mediated gene transfer, enhancement of transfection having been proposed to be in part through efficient nuclear targeting stemming from the resemblance of ply to the nuclear localization sequence (NLS) from simian virus SV40 large tumor antigen (T-ag). In this study we test whether ply carding covalently attached peptides comprising the T-ag NLS (the pLyP101 derivative) can enhance transferrin-pLy-mediated transfection...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Human Gene Therapy
DOI: 10.1089/10430349950017699


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