Skip navigation
Skip navigation

Oxidation and Reduction of Pig Skeletal Muscle Ryanodine Receptors

Haarmann, Claudia; Fink, Rainer; Dulhunty, Angela

Description

Time-dependent effects of cysteine modification were compared in skeletal ryanodine receptors (RyRs) from normal pigs and RyR(MH) (Arg615 to Cys615) from pigs susceptible to malignant hyperthermia, using the oxidizing reagents 4,4'-dithiodipyridine (4,4'-DTDP) and 5,5'-dithio-bis(2- nitrobenzoic acid) (DTNB) or the reducing agent dithiothreitol (DTT). Normal and RyR(MH) channels responded similarly to all reagents. DTNB (1 mM), either cytoplasmic (cis) or luminal (trans), or 1 mM 4,4'-DTDP...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
URI: http://hdl.handle.net/1885/92439
Source: Biophysical Journal

Download

File Description SizeFormat Image
01_Haarmann_Oxidation_and_Reduction_of_Pig_1999.pdf254.95 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator