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A Novel Approach for Modifying Tumor Cell - Derived Plasma Membrane Vesicles to Contain Encapsulated IL-2 and Engrafted Cosmimulatory Molecules for Use Tumor Immunotherapy

Van Broekhoven, Christina; Altin, Joseph


The genetic modification of tumor cells and delivery of cytokines have been proposed as useful strategies in the development of anti-tumor vaccines; however, a number of factors limit their use in clinical settings. To facilitate vaccine development, we explored the possibility of modifying plasma membrane vesicles (PMV) by using a novel chelator lipid, nitrilotriacetic acid ditetradecylamine (NTA-DTDA). Our analyses by flow cytometry show that NTA-DTDA can be incorporated into PMV prepared...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: International Journal of Cancer
DOI: 10.1002/ijc.10157


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