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Structure and Function of a Model Member of the SulP Transporter Family

Loughlin, Patrick; Shelden, Megan; Tierney, Mary (Louise); Howitt, Susan


SHST1 is a sulfate transporter that belongs to a large and diverse family of anion transporters. Little is known about the structure and function of any member of the family. Site-directed mutagenesis of SHST1 is being used to understand the function of particular amino acids. We have mutated highly conserved amino acid residues and the results suggest that the first two helices play an important role in the transport pathway. Furthermore, mutation of equivalent residues to those altered in...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Cell Biochemistry and Biophysics
DOI: 10.1385/CBB:36:2-3:183


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