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Changes in Chromatin Accessibility Across the GM-CSF Promoter upon T Cell Activation Are Dependent on Nuclear Factor kappaB Proteins

Holloway, Adele; Rao, Sudha; Chen, Xin; Shannon, M Frances


Granulocyte/macrophage colony-stimulating factor (GM-CSF) is a key cytokine in myelopoiesis and aberrant expression is associated with chronic inflammatory disease and myeloid leukemias. This aberrant expression is often associated with constitutive nuclear factor (NF)-κB activation. To investigate the relationship between NF-κB and GM-CSF transcription in a chromatin context, we analyzed the chromatin structure of the GM-CSF gene in T cells and the role of NF-κB proteins in chromatin...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20021039


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