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SOX9 has both conserved and novel roles in marsupial sexual differentiation

Pask, Andrew J; Harry, Jenny L; Graves, Jennifer; O'Neill, Rachel; Layfield, Sharon; Shaw, Geoffrey; Renfree, Marilyn B

Description

In addition to an essential role in chondrogenesis, SOX9 is a highly conserved and integral part of the testis determining pathway in human and mouse. To determine whether SOX9 is involved in sex determination in noneutherian mammals we cloned a marsupial orthologue and studied its expression. The tammar wallaby SOX9 gene proved to be highly conserved, and maps to a region of the tammar genome syntenic to human chromosome 17. Marsupial SOX9 transcripts were detected by RT-PCR in the developing...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/92260
Source: Genesis
DOI: 10.1002/gene.10096

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