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Sex chromosomes and sex determination in weird mammals

Graves, Jennifer

Description

Weird mammals are of two types. Highly divergent mammals, such as the marsupials and monotremes, have informed us of the evolutionary history of the Y chromosome and sex-determining gene, and the recently specialized rodents can help us predict its future. The Y chromosome has had a short but eventful history, and is already heading briskly for oblivion. It originated as a homologous partner of the X when it acquired a sex-determining gene (not necessarily SRY). Most of the genes on the Y, even...[Show more]

dc.contributor.authorGraves, Jennifer
dc.date.accessioned2015-12-13T23:24:31Z
dc.identifier.issn1424-8581
dc.identifier.urihttp://hdl.handle.net/1885/92255
dc.description.abstractWeird mammals are of two types. Highly divergent mammals, such as the marsupials and monotremes, have informed us of the evolutionary history of the Y chromosome and sex-determining gene, and the recently specialized rodents can help us predict its future. The Y chromosome has had a short but eventful history, and is already heading briskly for oblivion. It originated as a homologous partner of the X when it acquired a sex-determining gene (not necessarily SRY). Most of the genes on the Y, even those with a male-specific function, evolved from genes now on the X. At the mercy of a high rate of variability and the forces of drift and selection, the Y has lost genes at a rate of 3-6 genes/million years, sparing those that acquired critical male-specific functions. Even these genes have disappeared from one mammalian lineage or another as their functions were usurped by genes elsewhere in the genome. The mammalian testis-determining gene, SRY, is a typical Y-borne gene. It arose by truncation of a gene (SOX3) on the X that is expressed in brain development, and it may work by interacting with (inhibiting?) related genes, including SOX9. Variant sex-determining systems in rodents show that the action of SRY can change, as it evidently has in the mouse, and SRY can be inactivated, as in akodont rodents, or even completely superseded, as in mole voles.
dc.publisherS Karger AG
dc.sourceCytogenetic and Genome Research
dc.subjectKeywords: animal genetics; brain development; cell lineage; evolutionary homology; gene expression; gene function; gene interaction; genetic linkage; genetic variability; mammal; mammal cell; nonhuman; priority journal; review; sex chromosome; sex determination; se
dc.titleSex chromosomes and sex determination in weird mammals
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume96
dc.date.issued2002
local.identifier.absfor060403 - Developmental Genetics (incl. Sex Determination)
local.identifier.ariespublicationMigratedxPub23284
local.type.statusPublished Version
local.contributor.affiliationGraves, Jennifer, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage161
local.bibliographicCitation.lastpage168
local.identifier.doi10.1159/000063022
dc.date.updated2015-12-12T09:20:46Z
local.identifier.scopusID2-s2.0-0036045194
CollectionsANU Research Publications

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