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Modeling Diverse Range of Potassium Channels with Brownian Dynamics

Chung, Shin-Ho; Allen, Toby; Kuyucak, Serdar


Using the experimentally determined KcsA structure as a template, we propose a plausible explanation for the diversity of potassium channels seen in nature. A simplified model of KcsA is constructed from its atomic resolution structure by smoothing out the protein-water boundary and representing the atoms forming the channel protein as a homogeneous, low dielectric medium. The properties of the simplified and atomic-detail models, deduced from electrostatic calculations and Brownian dynamics...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Biophysical Journal


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