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Photolytic manipulation of [Ca2+]i reveals slow kinetics of potassium channels underlying the afterhyperpolarisation in hippocampal pyramidal neurons

Sah, Pankaj; Clements, John D


The identity of the potassium channel underlying the slow, apamin- insensitive component of the afterhyperpolarization current (S/(AHP)) remains unknown. We studied S/(AHP) in CA1 pyramidal neurons using simultaneous whole-cell recording, calcium fluorescence imaging, and flash photolysis of caged compounds. Intracellular calcium concentration ([Ca2+](i)) peaked earlier and decayed more rapidly than S/(AHP). Loading cells with low concentrations of the calcium chelator EGTA slowed the...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Neuroscience


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