Photolytic manipulation of [Ca2+]i reveals slow kinetics of potassium channels underlying the afterhyperpolarisation in hippocampal pyramidal neurons
The identity of the potassium channel underlying the slow, apamin- insensitive component of the afterhyperpolarization current (S/(AHP)) remains unknown. We studied S/(AHP) in CA1 pyramidal neurons using simultaneous whole-cell recording, calcium fluorescence imaging, and flash photolysis of caged compounds. Intracellular calcium concentration ([Ca2+](i)) peaked earlier and decayed more rapidly than S/(AHP). Loading cells with low concentrations of the calcium chelator EGTA slowed the...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Neuroscience|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.