pH Regulation in the Intracellular Malaria Parasite, Plasmodium falciparum: H+ extrusion via a V-Type H+ -ATPase
The mechanism by which the intra-erythrocytic form of the human malaria parasite, Plasmodium falciparum, extrudes H+ ions and thereby regulates its cytosolic pH (pH(i)), was investigated using saponin-permeabilized parasitized erythrocytes. The parasite was able both to maintain its resting PH(i) and to recover from an imposed intracellular acidification in the absence of extracellular Na+, thus ruling out the involvement of a Na+/H+ exchanger in both processes. Both phenomena were...[Show more]
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|Source:||Journal of Biological Chemistry|
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