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pH Regulation in the Intracellular Malaria Parasite, Plasmodium falciparum: H+ extrusion via a V-Type H+ -ATPase

Saliba, Kevin; Kirk, Kiaran


The mechanism by which the intra-erythrocytic form of the human malaria parasite, Plasmodium falciparum, extrudes H+ ions and thereby regulates its cytosolic pH (pH(i)), was investigated using saponin-permeabilized parasitized erythrocytes. The parasite was able both to maintain its resting PH(i) and to recover from an imposed intracellular acidification in the absence of extracellular Na+, thus ruling out the involvement of a Na+/H+ exchanger in both processes. Both phenomena were...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.274.47.33213


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