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Calothrixins A and B, Novel Pentacyclic Metabolites from Calothrix Cyanobacteria with Potent Activity against Malaria Parasites and Human Cancer Cells

Rickards, Rodney; Rothschild, Jennifer; Willis, Anthony; de Chazel, Nola; Kirk, J; Kirk, Kiaran; Saliba, Kevin; Smith, Geoffrey D


Cell extracts from photoautrophic cultures of two cyanobacterial Calothrix isolates inhibited the growth in vitro of a chloroquine-resistant strain of the malaria parasite, Plasmodium falciparum, and of human HeLa cancer cells, in a dose-dependent manner. Bioassay-directed fractionation of the extracts led to the isolation and structural characterization of calothrixins A (1) and B (2), pentacyclic metabolites with an indolo[3,2- j]phenanthridine ring system unique amongst natural products,...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Tetrahedron
DOI: 10.1016/S0040-4020(99)00833-9


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