Novel metal complex synthons for chiral 4-azaleucine, 2,3-diaminopropanoic acid and its elaboration
Efficient syntheses of chiral Co(III) complexes with 2,3-diaminopropanoic acid (A2pr) have been developed. In these complexes, the amino acid zwitterion [A2pr(H+)O-] is bound didentate through the carboxylate and N2-amine groups while the N3-ammonio group [pKa = 7.19(2)] is unprotected. Syntheses of Λ(+)578- and Δ(-)578-[(en)2Co-(5-A2pr(H +)O)]Cl3·H2O were effected stereoretentively from the similarly didentate aspartato complexes Λ- and Δ-[(en)2Co(S-Asp(OH)O)]Cl2 in reaction sequences...[Show more]
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