Serotype 1a O-Antigen Modification: Molecular Characterization of the Genes Involved and Their Novel Organisation in the Shigella Flexneri Chromosome
The factors responsible for serotype 1a O-antigen modification in Shigella flexneri were localized to a 5.8-kb chromosomal HindIII fragment of serotype 1a strain Y53. The entire 5.8-kb fragment and regions up- and downstream of it (10.6-kb total) were sequenced. A putative three-gene operon, which showed homology with other serotype conversion genes, was identified and shown to confer serotype 1a O-antigen modification. The serotype conversion genes were flanked on either side by phage DNA....[Show more]
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|Source:||Journal of Bacteriology|
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