Garcia De Vinuesa, Maria Carola; Cook, Matthew C; Cooke, Michael P; MacLennan, Ian C M; Goodnow, Christopher
DNA microarray analysis of B cell subsets has identified comprehensive programs of gene expression that distinguish B cells at discrete stages of differentiation. The next task is to identify key genetic signals within these complex programs that regulate the dynamic cellular events during B cell activation in vivo. After stimulation with antigen, naïve B cells proliferate and differentiate, and then produce antibodies. Crucial qualitative differences in antibody responses are observed...[Show more]
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