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Immune response to rotavirus VP4 expressed in an attenuated strain of Shigella Flexneri

Loy, A; Allison, Gwen; Arias, Carlos; Verma, Naresh


An attenuated strain of Shigella flexneri was utilised to express viral protein (VP) 4 of rotavirus and the immunogenicity of the recombinant constructs was studied in BALB/c mice. VP4 was expressed as a fusion with maltose binding protein (MBP) in both the cytoplasm and periplasm, with a much higher level of expression occurring in the former. While all constructs induced a Shigella-specific response in mice, only the construct expressing MBP-VP4 in the cytoplasm of Shigella stimulated an...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: FEMS Immunology and Medical Microbiology
DOI: 10.1016/S0928-8244(99)00098-X


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