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The role of natriuretic peptides in ion transport mechanisms

Kourie, Joseph


Natriuretic peptides (NP) act as ligands on the guanylyl cyclase family of receptors. The NP binding site on these receptors is extracellular and the guanylyl cyclase and protein kinase domains are intracellular. The guanylyl cyclase receptor catalyzes the synthesis of the second messenger molecule, cGMP, which activates protein kinase. This in turn is involved in the phosphorylation of various ion transport proteins. Ion transport proteins, which are modulated by NP and are thought to underlie...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Medical Research Reviews
DOI: 10.1002/(SICI)1098-1128(199901)19:1<75::AID-MED4>3.0.CO;2-6


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