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Characterization of a C-type natriuretic peptide (CNP-39)-formed cation-selective channel from platypus (Ornithrorhynchus anatinus) venom

Kourie, Joseph

Description

1. The lipid bilayer technique is used to characterize the biophysical and pharmacological properties of a novel, fast, cation-selective channel formed by incorporating platypus (Ornithorhynchus anatinus) venom (OaV) into lipid membranes. 2. A synthetic C-type natriuretic peptide OaCNP-39, which is identical to that present in platypus venom, mimics the conductance, kinetics, selectivity and pharmacological properties of the OaV-formed fast cation-selective channel. The N-terminal fragment...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
URI: http://hdl.handle.net/1885/91561
Source: Journal of Physiology
DOI: 10.1111/j.1469-7793.1999.0359p.x

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