Characterization of a C-type natriuretic peptide (CNP-39)-formed cation-selective channel from platypus (Ornithrorhynchus anatinus) venom
1. The lipid bilayer technique is used to characterize the biophysical and pharmacological properties of a novel, fast, cation-selective channel formed by incorporating platypus (Ornithorhynchus anatinus) venom (OaV) into lipid membranes. 2. A synthetic C-type natriuretic peptide OaCNP-39, which is identical to that present in platypus venom, mimics the conductance, kinetics, selectivity and pharmacological properties of the OaV-formed fast cation-selective channel. The N-terminal fragment...[Show more]
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|Source:||Journal of Physiology|
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