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Hydrogen peroxide inhibits chloride channels of the sarcoplasmic reticulum of skeletal muscle

Kourie, Joseph


Data obtained with the lipid bilayer technique indicate that cis (cytoplasmic) concentration of 4.4-22 mm hydrogen peroxide (H2O2), is a water-soluble oxidant. [H2O2](cis) (n = 26) reversibly inhibits the multisubconductance SCl channel of the sarcoplasmic reticulum vesicles from rabbit skeletal muscle. At -40 mV, the mean values of the current amplitude (I) and the probability of the SCl channel being open (P(0)) were reduced significantly (n = 8) from -6.14 ± 0.42 pA and 0.69 ± 0.06 (for all...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Membrane Biology
DOI: 10.1007/s002329900580


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