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Antigen-specific systemic and reproductive tract antibodies in foxes immunized with salmonella typhimurium expressing bacterial and sperm proteins

Bird, Phillip I; Verma, Naresh; Bradley, Mark P


Attenuated Salmonella typhimurium strains are potential 'safe' delivery vectors of an oral immunocontraceptive vaccine for the European red fox (Vulpes vulpes). In the present study, model bacterial (Escherichia coli heat-labile enterotoxin B subunit, LTB) and fox sperm (fSP10) antigens were expressed in S. typhimurium SL3261 (ΔaroA) under the control of the trc promoter. Adult female foxes were given three oral immunizations with SL3261 containing either LTB (SL3261/pLTB), fSP10...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Reproduction, Fertility and Development


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