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Malaria parasite specific TH1-like cells simultaneously reduce parasitaemia and promote disease

Hirunpetcharat, Chakrit; Finkelman, Fred; Clark, Ian A; Good, Michael


CD4+ T cells have been implicated in immunity to the blood stages of malaria and cytokines associated with both monocyte and T cell activation have been implicated in disease. To determine whether specific T cells capable of inhibiting parasite growth can also mediate pathology we have transfused populations of Plasmodium berghei-specific T cells into normal and immunodeficient naive mice. We observed that they could inhibit parasite growth but were unable to save the animals which exhibited...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Parasite Immunology
DOI: 10.1046/j.1365-3024.1999.00234.x


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