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Hydrolysis of the 5'- p -Nitrophenyl Ester of TMP by the Proofreading Exonuclease (ε) Subunit of Escherichia coli DNA Polymerase III

Hamdan, Samir; Bulloch, Esther; Thompson, Phillip; Beck, Jennifer; Yang, Ji Yeon; Crowther, Jeffrey; Lilley, Penelope; Carr, Paul D; Ollis, David; Brown, Susan Elizabeth; Dixon, Nicholas

Description

The core of DNA polymerase III, the replicative polymerase in Escherichia coli, consists of three subunits (α, ε, and θ). The ε subunit is the 3′-5′ proofreading exonuclease that associates with the polymerase (α) through its C-terminal region an

dc.contributor.authorHamdan, Samir
dc.contributor.authorBulloch, Esther
dc.contributor.authorThompson, Phillip
dc.contributor.authorBeck, Jennifer
dc.contributor.authorYang, Ji Yeon
dc.contributor.authorCrowther, Jeffrey
dc.contributor.authorLilley, Penelope
dc.contributor.authorCarr, Paul D
dc.contributor.authorOllis, David
dc.contributor.authorBrown, Susan Elizabeth
dc.contributor.authorDixon, Nicholas
dc.date.accessioned2015-12-13T23:22:26Z
dc.identifier.issn0006-2960
dc.identifier.urihttp://hdl.handle.net/1885/91445
dc.description.abstractThe core of DNA polymerase III, the replicative polymerase in Escherichia coli, consists of three subunits (α, ε, and θ). The ε subunit is the 3′-5′ proofreading exonuclease that associates with the polymerase (α) through its C-terminal region an
dc.publisherAmerican Chemical Society
dc.sourceBiochemistry
dc.subjectKeywords: 4 nitrophenyl 3' thymidylate; 4-nitrophenyl 3'-thymidylate; divalent cation; DNA directed DNA polymerase gamma; drug derivative; exodeoxyribonuclease; exodeoxyribonuclease V; magnesium; manganese; thymidine phosphate; ester derivative; exonuclease; magnes
dc.titleHydrolysis of the 5'- p -Nitrophenyl Ester of TMP by the Proofreading Exonuclease (ε) Subunit of Escherichia coli DNA Polymerase III
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume41
dc.date.issued2002
local.identifier.absfor030499 - Medicinal and Biomolecular Chemistry not elsewhere classified
local.identifier.ariespublicationMigratedxPub22200
local.type.statusPublished Version
local.contributor.affiliationHamdan, Samir, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBulloch, Esther, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationThompson, Phillip, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBeck, Jennifer, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationYang, Ji Yeon, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationCrowther, Jeffrey, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationLilley, Penelope, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationCarr, Paul D, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationOllis, David, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBrown, Susan Elizabeth, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationDixon, Nicholas, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue16
local.bibliographicCitation.startpage5266
local.bibliographicCitation.lastpage5275
local.identifier.doi10.1021/bi0159480
dc.date.updated2015-12-12T09:11:00Z
local.identifier.scopusID2-s2.0-0037161144
CollectionsANU Research Publications

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