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N-Fmoc-dehydroalanine: a versatile molecular scaffold for the rapid solid-phase synthesis of cycloaliphatic amino acids

Burkett, Brenden; Chai, Christina


The synthesis of polymer-supported N-Fmoc-dehydroalanine starting from S-protected cysteine via an oxidation/elimination strategy is described. Cycloaddition with a range of dienes afforded a range of conformationally constrained amino acids in moderate yields. The potential applications of this methodology to combinatorial libraries is discussed. (C) 2000 Elsevier Science Ltd.

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Tetrahedron Letters
DOI: 10.1016/S0040-4039(00)01113-8


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