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Permeation of ions across the potassium channel: Brownian dynamics studies

Chung, Shin-Ho; Allen, Toby; Hoyles, Matthew; Kuyucak, Serdar


The physical mechanisms underlying the transport of ions across a model potassium channel are described. The shape of the model channel corresponds closely to that deduced from crystallography. From electrostatic calculations, we show that an ion permeating the channel, in the absence of any residual charges, encounters an insurmountable energy barrier arising from induced surface charges. Carbonyl groups along the selectivity filter, helix dipoles near the oval chamber, and mouth dipoles near...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Biophysical Journal


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