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The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

Dimmer, Kai-Stefan; Friedrich, Bjorn; Lang, Florian; Deitmer, Joachim W; Broer, Stefan

Description

Transport of lactate and other monocarboxylates in mammalian cells is mediated by a family of transporters, designated monocarboxylate transporters (MCTs). The MCT4 member of this family has recently been identified as the major isoform of white muscle cells, mediating lactate efflux out of glycolytically active myocytes [Wilson, Jackson, Heddle, Price, Pilegaard, Juel, Bonen, Montgomery, Hutter and Halestrap (1998) J. Biol. Chem. 273, 15920-15926]. To analyse the functional properties of this...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/91164
Source: Biochemical Journal
DOI: 10.1042/0264-6021:3500219

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