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Tests of Continuum Theories as Models of Ion Channels. II. Poisson-Nernst-Planck Theory versus Brownian Dynamics

Corry, Ben; Kuyucak, Serdar; Chung, Shin-Ho


We test the validity of the mean-field approximation in Poisson-Nernst- Planck theory by contrasting its predictions with those of Brownian dynamics simulations in schematic cylindrical channels and in a realistic potassium channel. Equivalence of the two theories in bulk situations is demonstrated in a control study. In simple cylindrical channels, considerable differences are found between the two theories with regard to the concentration profiles in the channel and its conductance...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Biophysical Journal


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