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A model of calcium channels

Corry, Ben; Allen, Toby; Kuyucak, Serdar; Chung, Shin-Ho


We propose a model of calcium channels that can explain most of their observed properties, including the anomalous mole fraction effect and mutation of the glutamate residues. The structure grossly resembles that of the KcsA potassium channel except for the presence of an extracellular vestibule and a shorter selectivity filter containing four glutamate residues. Using this model in electrostatic calculations and Brownian dynamics simulations, we study mechanisms of ion permeation and...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics
DOI: 10.1016/S0005-2736(00)00330-8


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