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Tests of Continuum Theories as Models of Ion Channels. I. Poisson-Boltzmann Theory versus Brownian Dynamics

Moy, G; Corry, Ben; Kuyucak, Serdar; Chung, Shin-Ho


Continuum theories of electrolytes are widely used to describe physical processes in various biological systems. Although these are well-established theories in macroscopic situations, it is not clear from the outset that they should work in small systems whose dimensions are comparable to or smaller than the Debye length. Here, we test the validity of the mean-field approximation in Poisson-Boltzmann theory by comparing its predictions with those of Brownian dynamics simulations. For this...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Biophysical Journal


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