Identification of progenitor cells in long-term spleen stromal cultures that produce immature dendritic cells
Dendritic cells (DC) are produced continuously by a unique, longterm culture (LTC) system in which hemopoiesis is supported by a splenic stromal cell layer in the absence of added growth factors. Flow cytometric analysis reveals the production of two distinct cell subsets. The more predominant large-cell subset resembles highly endocytic DC that are large, granular, and possess membrane extensions. They also express high levels of the DC markers CD11c, CD11b, DEC-205, and CD80 on their cell...[Show more]
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