Proliferation of dendritic cell progenitors in long term culture is not dependent on granulocyte macrophage-colony stimulating factor
A unique long term culture (LTC) system has been developed which supports the production of dendritic cells (DC). Cell production is dependent on a stromal cell layer derived from murine spleen. This LTC system produces a high turnover of non-adherent cells that express DC morphology, cell- surface markers, and antigen-presenting capacity. Objective The long term production of these cells suggests that the LTC system supports hemopoiesis. It was of interest to examine the number and nature of...[Show more]
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