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The same amino acid substitution in orthologous esterases confers organophosphate resistance on the house fly and a blowfly

Claudianos, Charles; Russell, Robyn; Oakeshott, John Graham

Description

Organophosphate (OP) insecticide resistance in certain strains of Musca domestica is associated with reduction in the carboxylesterase activity of a particular esterase isozyme. This has been attributed to a 'mutant ali- esterase hypothesis', which invokes a structural mutation to an ali-esterase resulting in the loss of its carboxylesterase activity but acquisition of OP hydrolase activity. It has been shown that the mutation in Lucilia cuprina is a Gly137 → Asp substitution in the active site...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
URI: http://hdl.handle.net/1885/90830
Source: Insect Biochemistry and Molecular Biology
DOI: 10.1016/S0965-1748(99)00035-1

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