The same amino acid substitution in orthologous esterases confers organophosphate resistance on the house fly and a blowfly
Organophosphate (OP) insecticide resistance in certain strains of Musca domestica is associated with reduction in the carboxylesterase activity of a particular esterase isozyme. This has been attributed to a 'mutant ali- esterase hypothesis', which invokes a structural mutation to an ali-esterase resulting in the loss of its carboxylesterase activity but acquisition of OP hydrolase activity. It has been shown that the mutation in Lucilia cuprina is a Gly137 → Asp substitution in the active site...[Show more]
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|Source:||Insect Biochemistry and Molecular Biology|
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