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Alterations in ciliary neurotrophic factor signaling in rapsyn deficient mice

Bartlett, Selena; Banks, G D; Reynolds, Anna; Waters, Mike; Hendry, Ian; Noakes, Peter G

Description

Rapsyn is a key molecule involved in the formation of postsynaptic specializations at the neuromuscular junction, in its absence there are both pre- and post-synaptic deficits including failure to cluster acetylcholine receptors. Recently we have documented increases in both nerve-muscle branching and numbers of motoneurons, suggesting alterations in skeletal muscle derived trophic support for motoneurons. The aim of the present study was to evaluate the contribution of target derived trophic...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/90810
Source: Journal of Neuroscience Research
DOI: 10.1002/jnr.1109

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