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Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer

Bamber, Dianne; Board, Philip; Coggan, Marjorie; Elder, James; Deakin, Mark; Rajagopal, Ramesh; Fawole, A. Sergei; Strange, Richard; Fryer, Anthony

Description

We have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results suggest that two of the sites are in linkage disequilibrium with each other and with GSTT1 genotype. Clinical parameters such as Duke's stage, differentiation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 polymorphisms and Dukeís stage. This preliminary...[Show more]

dc.contributor.authorBamber, Dianne
dc.contributor.authorBoard, Philip
dc.contributor.authorCoggan, Marjorie
dc.contributor.authorElder, James
dc.contributor.authorDeakin, Mark
dc.contributor.authorRajagopal, Ramesh
dc.contributor.authorFawole, A. Sergei
dc.contributor.authorStrange, Richard
dc.contributor.authorFryer, Anthony
dc.date.accessioned2015-12-13T23:20:30Z
dc.date.available2015-12-13T23:20:30Z
dc.identifier.issn0009-2797
dc.identifier.urihttp://hdl.handle.net/1885/90730
dc.description.abstractWe have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results suggest that two of the sites are in linkage disequilibrium with each other and with GSTT1 genotype. Clinical parameters such as Duke's stage, differentiation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 polymorphisms and Dukeís stage. This preliminary data suggests that polymorphism at GSTT2 may be significant in determining outcome in colorectal cancer.
dc.publisherElsevier
dc.sourceChemico-Biological Interactions
dc.subjectKeywords: Colorectal cancer; Duke's stage; GSTT2; Polymorphism
dc.titleGlutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume133
dc.date.issued2001
local.identifier.absfor111299 - Oncology and Carcinogenesis not elsewhere classified
local.identifier.ariespublicationMigratedxPub21169
local.type.statusPublished Version
local.contributor.affiliationBamber, Dianne, Keele University, North Staffordshire Hospital
local.contributor.affiliationBoard, Philip, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCoggan, Marjorie, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationElder, James, Keele University, North Staffordshire Hospital
local.contributor.affiliationDeakin, Mark, Keele University, North Staffordshire Hospital
local.contributor.affiliationRajagopal, Ramesh, Keele University, North Staffordshire Hospital
local.contributor.affiliationFawole, A. Sergei, Keele University, North Staffordshire Hospital
local.contributor.affiliationStrange, Richard, Keele University, North Staffordshire Hospital
local.contributor.affiliationFryer, Anthony, Keele University, North Staffordshire Hospital
local.bibliographicCitation.startpage95
local.bibliographicCitation.lastpage97
dc.date.updated2015-12-12T09:03:21Z
local.identifier.scopusID2-s2.0-0003129133
CollectionsANU Research Publications

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