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Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer

Bamber, Dianne; Board, Philip; Coggan, Marjorie; Elder, James; Deakin, Mark; Rajagopal, Ramesh; Fawole, A. Sergei; Strange, Richard; Fryer, Anthony


We have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results suggest that two of the sites are in linkage disequilibrium with each other and with GSTT1 genotype. Clinical parameters such as Duke's stage, differentiation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 polymorphisms and Dukeís stage. This preliminary...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Chemico-Biological Interactions


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