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Early rise in blood pressure following administration of adrenocorticotropic hormone-(1-24) in humans

Jackson, Richard; Nye, E; Grice, Jeffrey E; Hockings, G; Strakosch, C; Walters, M; Crosbie, G; Torpy, David J; Whitworth, Judith


1. An elevation in blood pressure has been consistently observed 24 h after adrenocorticotropic hormone (ACTH) administration and is caused by increased ACTH-stimulated cortisol secretion, in association with increased cardiac output. The aim of the present study was to investigate the previously undefined time of onset of this increase in blood pressure in normal humans. 2. Ten normal healthy volunteers received 250 μg ACTH-[1-24], in 500 mL normal saline, infused at a constant rate over 8 h....[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1046/j.1440-1681.2001.03518.x


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