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Circadian blood pressure variability in adrenocorticotrophin-induced hypertension in the rat

Turner, Steven; Fraser, Tafline; Mangos, George; Whitworth, Judith


Objectives. Secondary hypertension is often characterized by loss of diurnal blood pressure variability. This study examined circadian (24 h) blood pressure variability in adrenocorticotrophin (ACTH)-induced hypertension in the Sprague-Dawley rat. Methods. Male Sprague-Dawley rats were randomly allocated to sham (0.9% saline, s.c.), n = (9), ACTH (0.5 μg/kg per day, s.c., n = 8) or ACTH (100 μg/kg per day, s.c., n = 7) in a room with a 12 h light/dark cycle (0600 h to 1800 h). A radio telemetry...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Hypertension
DOI: 10.1097/00004872-200108000-00009


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