Hybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa
-
Altmetric Citations
Ernst-Russell, M; Elix, John; Chai, Christina; Willis, Anthony; Hamada, Nabuo; Nash, Thomas
Description
Hybocarpone (1), a novel pentacyclic naphthazarin-derived dimer has been isolated from mycobiont cultures derived from the lichen Lecanora hybocarpa. The structure of hybocarpone (1) was established on the basis of 1D and 2D NMR spectroscopy. Its relative stereochemistry was predicted with the use of molecular modelling and confirmed by X-ray crystallographic analysis. Hybocarpone (1) was found to be a potent cytotoxin (IC50 c 0.27 μM), active against the murine P815 mastocytoma cell line.
Collections | ANU Research Publications |
---|---|
Date published: | 1999 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/90652 |
Source: | Tetrahedron Letters |
DOI: | 10.1016/S0040-4039(99)01220-4 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Ernst-Russell_Hybocarpone,_a_novel_cytotoxic_1999.pdf | 245.44 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator