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Analogues of SB-203207 as Inhibitors of tRNA Synthetases

Banwell, Martin; Crasto, Curtis; Easton, Christopher; Forrest, Andrew; Karoli, Tomislav; March, Darren; Mensah, Lucy; Nairn, Michael; O'Hanlon, Peter; Oldham, Mark; Yue, Weimin

Description

SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine and

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/90554
Source: Bioorganic and Medicinal Chemistry Letters
DOI: 10.1016/S0960-894X(00)00456-X

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