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Total synthesis of herboxidiene, a complex polyketide from Streptomyces species A7847

Banwell, Martin; McLeod, Malcolm; Premraj, Rajaratnam; Simpson, Gregory Wayne


A formal total synthesis of the polyketide herboxidiene (1) has been achieved by Homer-Wittig coupling of the side-chain fragment 12-epi-(2) with the tetrahydropyran-2-acetic acid derivative (3) followed by desilylation of the resulting triene (19) and hydroxyl-directed mono-epoxidation of the ensuing bis-homoallylic alcohol (20).

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Pure and Applied Chemistry


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