Potential inhibition of somatic hypermutation by nucleoside analogues
Somatic hypermutation, which occurs in antigen-activated germinal centre B lymphocytes, diversifies the genes that encode immunoglobulin variable regions and leads to the 'affinity maturation' of the humoral immune response. Hypermutation affects dC/dG and dA/dT pairs with approximately equal frequency in vivo. DNA polymerase-θ contributes to hypermutagenesis at dC/dG pairs and DNA polymerase-η is substantially involved in the generation of hypermutations at dA/dT pairs. The biochemical...[Show more]
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