Potential inhibition of somatic hypermutation by nucleoside analogues
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Franklin, Andrew; Blanden, Robert
Description
Somatic hypermutation, which occurs in antigen-activated germinal centre B lymphocytes, diversifies the genes that encode immunoglobulin variable regions and leads to the 'affinity maturation' of the humoral immune response. Hypermutation affects dC/dG and dA/dT pairs with approximately equal frequency in vivo. DNA polymerase-θ contributes to hypermutagenesis at dC/dG pairs and DNA polymerase-η is substantially involved in the generation of hypermutations at dA/dT pairs. The biochemical...[Show more]
Collections | ANU Research Publications |
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Date published: | 2007 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/90449 |
Source: | Molecular Immunology |
DOI: | 10.1016/j.molimm.2006.02.022 |
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