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Homologous mutations in two diverse sulphate transporters have similar effects

Khurana, O; Coupland, Lucy; Shelden, Megan; Howitt, Susan

Description

Mutations in the human sulphate transporter gene, DTDST, have been implicated in several diseases. Analysis of affected patients has linked disease symptoms to faulty sulphate transporter activity. We have reproduced two of these mutations in SHST1, a homologous member of the family isolated from the tropical legume, Stylosanthes hamata. Both mutations significantly reduce sulphate transport activity of SHST1. These results indicate that conserved residues between distinct members of the family...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/90434
Source: FEBS Letters
DOI: 10.1016/S0014-5793(00)01783-X

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