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IDENTIFICATION AND CHARACTERIZATION OF THE ZETA CLASS OF GLUTATHIONE TRANSFERASES

Board, Philip; Chelvanayagam, Gareth; Jermiin, Lars; Blackburn, Anneke

Description

A new class of glutathione transferase isoenzymes has been identified by sequence data base analysis. The Zeta class isoenzymes occur in a wide range of species including plants, insects and mammals. The human enzyme has been shown to catalyse the glutathione dependent transformation of dichloroacetic acid to glyoxylic acid and the isomerization of maleylacetoacetate to fumarylacetoacetate. The latter reaction is an essential step in the catabolism of tyrosine. The GSTZ1 gene is composed of 9...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/90397
Source: Clinical Chemistry and Enzymology Communications

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