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Spontaneously opening GABA (A) channels in AA1 pyramidal neurones of rat hippocampus

Birnir, Bryndis; Everitt, Andrea; Lim, Michelle; Gage, Peter


Spontaneous, single channel, chloride currents were recorded in 48% of cell-attached patches on neurones in the CA1 region of rat hippocampal slices. In some patches, there was more than 1 channel active. They showed outward rectification: both channel conductance and open probability were greater at depolarized than at hyperpolarized potentials. Channels activated by γ-aminobutyric acid (GABA) in silent patches on the same neurones had similar conductance and outward rectification. The...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Membrane Biology
DOI: 10.1007/s002320001028


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