A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo
IL-5 is generally regarded as a Th2 cytokine involved in eosinophil maturation and function and in B cell growth and antibody production, but without any well-established effects on T cells. Early reports suggested that IL-5 could stimulate the production of cytotoxic T lymphocytes (CTL) in vitro, but no evidence has been obtained to date for such a role in studies with IL-deficient (IL-5(-/-)) mice. Here we demonstrate that when oxidized mannan MUC1 fusion protein (M-FP) is used as an antigen...[Show more]
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|Source:||European Journal of Immunology|
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