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A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo

Apostolopoulos, Vasso; McKenzie, Ian F C; Lees, Catherine; Matthaei, Klaus; Young, I M


IL-5 is generally regarded as a Th2 cytokine involved in eosinophil maturation and function and in B cell growth and antibody production, but without any well-established effects on T cells. Early reports suggested that IL-5 could stimulate the production of cytotoxic T lymphocytes (CTL) in vitro, but no evidence has been obtained to date for such a role in studies with IL-deficient (IL-5(-/-)) mice. Here we demonstrate that when oxidized mannan MUC1 fusion protein (M-FP) is used as an antigen...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: European Journal of Immunology
DOI: 10.1002/1521-4141(200006)30:6<1733::AID-IMMU1733>3.0.CO;2-E


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