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Organic Osmolyte Channels: A Comparative View

Junankar, Pauline; Kirk, Kiaran


Cells respond to osmotic swelling by releasing inorganic ions and small organic molecules (organic osmolytes). In many cell-types, osmotic swelling results in the activation of an outwardly-rectifying anion-selective current. The channel underlying this current has a significant permeability to a number of organic osmolytes and may play a role in the hypoosmotically-activated efflux of these compounds. However, there is also evidence that the volume-regulatory efflux of organic osmolytes...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Cellular Physiology and Biochemistry
DOI: 10.1159/000016368


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