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Non-oxidative modification of lens crystallins by kynurenine: a novel post-translational protein modification with possible relevance to ageing and cataract

Garner, Brett; Shaw, Denis; Lindner, Robin; Carver, John; Truscott, R


In humans, the crystallin proteins of the ocular lens become yellow- coloured and fluorescent with ageing. With the development of senile nuclear cataract, the crystallins become brown and additional fluorophores are formed. The mechanism underlying crystallin colouration is not known but may involve interaction with kynurenine-derived UV filter compounds. We have recently identified a sulphur-linked glutathionyl-3-hydroxykynurenine glucoside adduct in the lens and speculated that kynurenine...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics
DOI: 10.1016/S0167-4838(99)00234-4


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