Garner, Brett; Shaw, Denis; Lindner, Robin; Carver, John; Truscott, R
In humans, the crystallin proteins of the ocular lens become yellow- coloured and fluorescent with ageing. With the development of senile nuclear cataract, the crystallins become brown and additional fluorophores are formed. The mechanism underlying crystallin colouration is not known but may involve interaction with kynurenine-derived UV filter compounds. We have recently identified a sulphur-linked glutathionyl-3-hydroxykynurenine glucoside adduct in the lens and speculated that kynurenine...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.