DNA Interactions and Bacterial Mutagenicity of Some Chromium(III) Imine Complexes and their Chromium(V) Analogues. Evidence for Chromium(V) Intermediates in the Genotoxicity of Chromium(III)
The in vitro DNA interactions and bacterial mutagenicities of cis-[CrIII(phen)2(OH2)2]3+ and trans-[CrIII(salen)(OH2)2]+ and their CrV analogues are reported. At pH 3.3, cis-[Cr(phen)2(OH2)2]3+ (0.02-2.0 mM) causes negatively supercoiled pUC9 DNA to smear on agarose gels, with substantial precipitation in the well at ≥1.0 mM. Much weaker interactions between CrIII and DNA were apparent at pH 7.4. The interactions between DNA and CrV phen complexes (0.5 mM total Cr, pH 3.3) generated by...[Show more]
|Collections||ANU Research Publications|
|Source:||Australian Journal of Chemistry|
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