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pH-Controlled Quaternary States of Hexameric DnaB Helicase

Donate, Luis Enrique; Llorca, O; Barcena, M; Brown, Susan Elizabeth; Dixon, Nicholas; Carazo, Jose-Maria


DnaB is the major helicase in the Escherichia coli replisome. It is a homohexameric enzyme that interacts with many other replisomal proteins and cofactors. It is usually loaded onto a single strand of DNA at origins of replication from its complex with its loading partner DnaC, then translocates in the 5' to 3' direction, unwinding duplex DNA in an NTP-driven process. Quaternary polymorphism has been described for the DnaB oligomer, a feature it has in common with some other hexameric...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Molecular Biology
DOI: 10.1006/jmbi.2000.4132


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